The present invention is directed to compounds that are inhibitors of the deubiquitinating enzyme, USP14, encompassed by the Formulae (I), (la) and (lb), compositions thereof, methods for the treatment of a condition associated with a dysfunction in proteostasis, methods for enhancing proteasome activity and methods for treating conditions associated with proteostasis dysfunction, such as cancer or tumor.La présente invention concerne des composés ayant la formule (I), (la) ou (Ib), des compositions les comprenant et des procédés pour le traitement d'une pathologie associée à un dysfonctionnement de la protéostase.
