Juan LOPEZ DE SILANES,Rita G. MANCILLA NAVA,Jorge F. PANIAGUA-SOLÍS,Alejandro ALAGÓN CANO,Walter GARCÍA UBBELOHDE
申请号：
US13298778
公开号：
US20120064063A1
申请日:
2011.11.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is directed to a pharmaceutical composition comprising F(ab′)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab′)2 antibody fragments using scrum or blood plasma of a mammal that has been previously immunized as a source of antibodies. The serum or blood plasma is digested with an enzyme pepsin, followed by separation and purification until the pharmaceutical composition of F(ab′)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
