The present invention provides a novel orally IgY preparation and process thereof, wherein the preparation is a W/O/W- type. The orally IgY embedded preparation of the present invention has high stability, and is resistant to gastric acid.本發明係提供一種用於水產動物之蛋黃免疫球體蛋白(IgY)口服製劑及其製備方法,其為一種水包油包水型製劑。本發明之IgY口服製劑具有高穩定性且可抗胃酸,抗病效果極佳。