PURPOSE: A composition containing Inula japonica Thunberg extract for preventing and treating avian influenza H5N1 infection is provided to ensure antiviral activity to H5N1. CONSTITUTION: A pharmaceutical composition for preventing and treating highly pathogenic avian influenza H5N1 infection contains Inula japonica Thunberg extract as an active ingredient. The pharmaceutical composition further contains a carrier, excipient, and diluent. A health food for preventing and treating H5N1 avian influenza H5N1 infection contains Inula japonica Thunberg extract as an active ingredient.본 발명은 고병원성 조류인플루엔자 H5N1에 항바이러스 활성을 갖는 선복화 추출물을 함유하는 고병원성 조류인플루엔자 H5N1 감염 예방 및 치료용 조성물을 제공한다.