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PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE INTESTINE (IBD)
专利权人:
НОРДИК ФАРМА (FR);ДИСФАР ИНТЕРНЭШНЛ БВ (NL)
发明人:
ШРАМ Ханс (FR),УГВОКЕ Михаэль Икечукву (NL),БУТТАФОКО Лаура (NL)
申请号:
RU2012106898/15
公开号:
RU2012106898A
申请日:
2010.08.25
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A pharmaceutical composition comprising: a. prednisolone metasulfobenzoate (PMSB) or its pharmaceutically acceptable salts, preferably sodium prednisolone metasulfobenzoate, ib. 5-ASA (5-aminosalicylic acid), its derivatives or its pharmaceutically acceptable salts. 2. The pharmaceutical composition according to claim 1 in the form of a powder, granules or suspension, preferably for use in the form of a tablet, enema, foam, oral dosage form, quick-release form, delayed-release form or delayed-release form. The pharmaceutical composition according to claim 1 or 2, suitable for rectal administration. The pharmaceutical composition according to claim 1, comprising a combination of prednisone metasulfobenzoate (PMSB) and 5-aminosalicylic acid (5-ASA), their derivatives or their pharmaceutically acceptable salts, in the form of a solid pharmaceutical composition, preferably for reconstitution to produce an enema. The pharmaceutical composition according to any one of claims 1 and 2, substantially free of buffer. The pharmaceutical composition according to claim 1, further comprising a viscosity enhancer, preferably in an amount of from about 0.05 to about 2.5 wt.%, More preferably in an amount of from about 1 to about 1.75 wt.%. The pharmaceutical composition according to claim 6, characterized in that the viscosity enhancer is selected from gum arabic, locust bean gum, agar gum, xanthan gum, guar gum, dextrin, xylitol, erythritol, tragacanth, fructose, sorbic acid, poloxamer, carrageenan, ethylene diamine acid tetra cellulose derivatives, carboxymethyl cellulose or hydroxypropyl methyl cellulose, and pre1. Фармацевтическая композиция, содержащая:а. преднизолон метасульфобензоат (ПМСБ) или его фармацевтически приемлемые соли, предпочтительно преднизолон метасульфобензоат натрия, иб. 5-АСК (5-аминосалициловая кислота), ее производные или ее фармацевтически приемлемые соли.2. Фармацевтическая композиция по п.1 в виде порошка, гранул или суспензии, предпочтительно для пр
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