A protective cover for a drainage tube cable tie protects a surgical patient from injury and/or infection. The protective cover includes a first fastener member having VELCRO® hooks on one side and pressure sensitive adhesive on the other side, a second fastener member having VELCRO® loops on one side and pressure sensitive adhesive on the other side, and an insert made of a flexible, relatively elastic material. An opening is formed through the first fastener member. The insert is placed over the opening and the pressure sensitive adhesive sides of the fastener members are pressed together in back-to-back relationship. The cable tie is positioned on the first fastener member over the opening and the insert, and the protective cover is wrapped around the cable tie and secured by engagement of the hooks with the loops to cover the cable tie and protect the patients skin.
