EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION;이화여자대학교 산학협력단
发明人:
SEO, Eun Kyoung,서은경,LEE, Yun Sil,이윤실,NAM, Joo Won,남주원,KIM, Seo Young,김서영
申请号：
KRKR2013/004280
公开号：
WO2013/172640A1
申请日:
2013.05.14
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
The present invention relates to a pharmaceutical composition having a heat shock protein induction activity and comprising a compound isolated from Eucommia ulmoides. The compound isolated from Eucommia ulmoides according to the present invention has a heat shock protein induction activity, and may particularly control the expression of HSF 1, HSP 27 and/or HSP 70. Thus, the composition of the present invention may provide the effects of protecting and regenerating cells through the induction of heat shock proteins and can be effectively used in treating or preventing nerve disorders, digestive diseases, enteropathy, renal diseases, eye diseases, cardiovascular diseases, or skin diseases. Further, the composition of the present invention can be effectively used as a cosmetic composition for regenerating damaged skin cells.L'invention concerne une composition pharmaceutique présentant une activité d'induction de protéines de choc thermique et contenant un composé isolé à partir d'Eucommia ulmoides. Ce composé présente une activité d'induction de protéines de choc thermique et peut, en particulier, réguler l'expression de HSF 1, HSP 27 et/ou HSP 70. La composition selon l'invention peut fournir des effets de protection et de régénération des cellules, par l'induction de protéines de choc thermique, et peut être utilisée efficacement dans le traitement ou la prévention des troubles nerveux, des maladies digestives, de l'entéropathie, des néphropathies, des maladies des yeux, des maladies cardio-vasculaires ou des maladies de la peau. La composition selon l'invention peut également être utilisée efficacement en tant que composition cosmétique pour la régénération de cellules cutanées lésées.본 발명은 열충격단백질 유도 활성을 갖는 두충으로부터 분리된 화합물을 포함하는 약학적 조성물에 관한 것이다. 본 발명에 따른 두충으로부터 분리된 화합물은 열충격단백질 유도 활성을 갖고 있으며 특히, HSF 1, HSP 27 및/또는 HSP 70의 발현을 조절할 수 있다. 이에 따라서 열충격단백질의 유도를 통해서 세포의 보호 및 재생 효과가 있으며 신경질환, 소화기질환, 장질환, 신질환, 안질환, 심혈관질환 또는 피부질환의 치료 또는 예방에 유용하게 사용될 수 있다. 또한, 손상된 피부 세포 재생용 화장
