Roberts, Anthony Simon,Kopsidas, George,Luke, Michael Ross,Jennings, Phil Anthony
申请号：
AU2017222700
公开号：
AU2017222700A1
申请日:
2017.02.27
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which binds to a first target antigen or epitope, the BDM being modified for selective binding to a heterologous target, coupled to a pharmacologically active protein or peptide which is an antibody or antigen-binding fragment thereof or a non-antibody protein or peptide which binds to a second target antigen or epitope, the BDMs being coupled to a C-terminus of a polypeptide present within the pharmacologically active protein or peptide.
