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Polysaccharide-protein conjugate vaccines
专利权人:
The United States of America; as represented by the Secretary of the Department of Health and Human Services
发明人:
Che-Hung Robert Lee,Carl E. Frasch
申请号:
US14270213
公开号:
US09198976B2
申请日:
2014.05.05
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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