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PATCH
专利权人:
HISAMITSU PHARMACEUTICAL CO.; INC.
发明人:
Masayuki SUZUKI,Hiroaki OKUTSU,Takashi YASUKOCHI,Yasunori TAKADA
申请号:
US15454066
公开号:
US20170172981A1
申请日:
2017.03.09
申请国别(地区):
US
年份:
2017
代理人:
摘要:
A patch for administering asenapine includes a support layer, and an adhesive agent layer formed on the support layer and including an adhesive base agent and asenapine and/or a pharmaceutically acceptable salt thereof. The adhesive base agent has a content in a range of 10 to 90% by mass in the adhesive agent layer and includes a natural rubber, polyisobutylene, an alkyl vinyl ether(co)polymer, polyisoprene, polybutadiene, a styrene-butadiene copolymer, a styrene-isoprene copolymer, a styrene-isoprene-styrene block copolymer, or a combination thereof. When a content of the asenapine and/or pharmaceutically acceptable salt thereof in terms of free asenapine in the adhesive agent layer is 3.4 mg, an AUC2-120 for a period starting from the time when the patch is brought into contact with a skin for 24 hours is 27,000 pg·hr/mL or more, and an AUC2-120 of an asenapine metabolite is 20% or less of the AUC2-120 of the free asenapine.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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