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Compositions and methods of inhibiting masp-1 and/or masp-2 and/or masp-3 for the treatment of various diseases and disorders
专利权人:
UNIVERSITY OF LEICESTER
发明人:
Demopulos Gregory A.,Schwaeble Hans-Wilhelm,Gray Patrick,Dudler Thomas
申请号:
NZ62947313
公开号:
NZ629473A
申请日:
2013.06.18
申请国别(地区):
NZ
年份:
2017
代理人:
摘要:
Disclosed is the use of a MASP-3 inhibitory agent in the manufacture of a medicament for treating a subject suffering from, or at risk for developing, a disease or disorder selected from the group consisting of age-related macular degeneration, arthritis, disseminated intravascular coagulation, thrombotic microangiopathy, asthma, dense deposit disease, pauci-immune necrotising crescentic glomerulonephritis, traumatic brain injury, aspiration pneumonia, endophthalmitis, neuromyelitis optica and Behcet’s disease, wherein said MASP-3 inhibitory agent is a MASP-3 monoclonal antibody, or fragment thereof that specifically binds to a portion of SEQ ID NO:8 and inhibits factor D maturation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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