MACDONALD, LYNN,STEVENS, SEAN,GURER, CAGAN,HOSIAWA, KAROLINA, A.,MURPHY, ANDREW, J.
申请号：
SG2013007893
公开号：
SG187673A1
申请日:
2011.08.02
申请国别(地区):
SG
年份:
2013
代理人:
摘要：
Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene segments, and J gene segments with at least one light chain V gene segment and at least one light chain J gene segment. Mice that make binding proteins that comprise a light chain variable domain operably linked to a heavy chain constant region are provided. Binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Modified cells, embryos, and mice that encode sequences for making the binding proteins are provided.
