A method of controlling weeds in a soybean or cotton field, which comprises the step of applying one or more 4-hydroxyphenylpyruvate dioxygenase inhibitory active compounds and flumioxazin in an effective amount to weeds in a soybean or cotton field, or a place where weeds would grow, said 4-hydroxyphenylpyruvate dioxygenase inhibitory active compounds being selected from the group consisting of isoxaflutole, mesotrione, sulcotrione, topramezone, pyrasulfotole, tembotrione and bicyclopyrone.
