Quinn Qun Zhu;Stephen K Picataggio;Daniel Joseph Macool;John E Seip;Zhixiong Xue;Howard Glenn Damude;Peter John Gillies;James John Ragghianti;Hongxiang Zhang;Narendra S Yadav
发明人:
Howard Glenn Damude,Peter John Gillies,Daniel Joseph Macool,Stephen K Picataggio,James John Ragghianti,John E Seip,Zhixiong Xue,Narendra S Yadav,Hongxiang Zhang,Quinn Qun Zhu
申请号：
US12466072
公开号：
US08685682B2
申请日:
2009.05.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil fraction is described. This strain comprises various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprises various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of DHA. Production host cells are claimed, as are methods for producing DHA within said host cells.
