The embodiment of this invention provides a type of moxibustion box that can solve the inconvenience of the current moxibustion technology. The moxibustion box comprises: a casing, wherein a top portion and a bottom portion of the casing are respectively provided with an opening, and a slot is provided at the bottom portion; a metal mesh sleeve, wherein the length of the sleeve is shorter than the length of the casing, an opening is provided on a top portion of the sleeve, and the rest of the sleeve has a mesh structure. The sleeve has a U-shaped cross-section. The shape of an inner wall of the sleeve corresponds to the shape used for moxa rolls and the outer wall of the sleeve corresponds with the shape of the casing. A top portion of the sleeve is provided with a protruding rim. When the sleeve is inserted into the casing through the top opening of the casing, the protruding rim forms an interference fit with an edge of the top opening. The moxibustion box further comprises a replaceable herbal container that can be placed at the bottom portion of the casing through the slot provided at the bottom portion of the casing. According to the embodiment of this invention, an herbal preparation or a tablet within the herbal container can improve an issue of the prior moxibustion technique in which the moxibustion box only provides therapeutic effects from a limited number of herbs such as moxa (Artemisiae Argyi) and ginger. The invention provides a large number of therapeutic options by using different herbs and medicine for different acupoints, introducing novel changes to the practice of traditional Chinese medicine.