Ross, Bruce S.,Sofia, Michael Joseph,Pamulapati, Ganapati Reddy,Rachakonda, Suguna,Zhang, Hai-Ren,Chun, Byoung-Kwon,Wang, Peiyuan
申请号：
HRP20171267
公开号：
HRP20171267T1
申请日:
2017.08.18
申请国别(地区):
HR
年份:
2017
代理人:
摘要：
Disclosed herein is a process for preparing an enantiomerically- or a diastereomerically enriched phosphorus-containing active, salt, or pharmaceutically acceptable salt thereof, of formula I-1 , which comprises the steps of: (a) reacting a protected or unprotected Active with a base to form a salt of said active and then reacting said salt with an enantiomerically- or a diastereomerically enriched compound of formula II-1 wherein the Active is a nucleoside, a nucleoside-analog, or a non-nucleoside.
