The present invention relates to a method for activating tumor-infiltrating lymphocytes (TILs) in a subject in need, particularly by administering to the subject a fermented composition generated via fermentation of symbiotic microbiota in a medium.本發明涉及在有需要的個體中活化腫瘤浸潤淋巴細胞(tumor-infiltrating lymphocytes,TIL)之方法,具體而言是透過向該個體施用經由在培養基中共生微生物群發酵而產生的發酵組合物。