苯基－３－氮雜－雙環［３．１．０］己－３－基－甲酮及其作為藥物之用途农业专利-农业学术服务平台

发明人:: GIOVANNINI, RICCARDO,吉欧维尼　瑞卡多,吉歐維尼　瑞卡多,BERTANI, BARBARA,伯塔尼　芭芭拉,FERRARA, MARCO,弗拉拉　马可,弗拉拉　馬可,LINGARD, IAIN,林卡德　伊恩,MAZZAFERRO, ROCCO,玛莎菲罗　洛可,瑪莎菲羅　洛可,ROSENBROCK, HOLGER,罗森布拉克　荷杰,羅森布拉克　荷傑,吉欧维尼瑞卡多,吉歐維尼瑞卡多,伯塔尼芭芭拉,弗拉拉马可,弗拉拉馬可,林卡德伊恩,玛莎菲罗洛可,瑪莎菲羅洛可,罗森布拉克荷杰,羅森布拉克荷傑

摘要：: The present inventions relates to substituted phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones of general formula (I) wherein R1, R2, R3, R4, R5 and R6 are as herein described or salts thereof, preferably pharmaceuti-cally acceptable salts thereof. The invention further relates to the manufacture of said compounds, pharmaceutical com-positions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various conditions such as conditions concerning positive and negative symptoms of schizophrenia as well as cognitive impairments associated with schizophrenia, Alzheimer’s Disease and other neurological and psychiatric disorders. The compounds of the invention show glycine transporter-1 (GlyT1) inhibiting properties.本發明係關於通式(I)之經取代之苯基-3-氮雜-雙環[3.1.0]己-3-基-甲酮或其鹽，較佳為其醫藥學上可接受之鹽，其中R1、R2、R3、R4、R5、R6及R7如本文中所述。本發明另外係關於該等化合物之製造，包含通式(I)之化合物之醫藥組合物，及該等化合物於治療各種病況上之用途，該等病況為諸如：涉及精神分裂症之正性及負性症狀之病況，及與精神分裂症、阿茲海默氏病(Alzheimer's Disease)及其他神經及精神病症有關之認知障礙。本發明化合物展現甘胺酸轉運體-1(GlyT1)抑制性質。