AN, DONG JUNKR,안동준,IM, SUNG INKR,임성인,CHOE, SE EUNKR,최세은,CHO, IN SOOKR,조인수,JEOUNG, HYE YOUNGKR,정혜영,SONG, JAE YOUNGKR,송재영,KIM, JAE JOKR,김재조,HAN, GYOO HAKR,한규하,HYUN, BANG HUNKR,현방훈,KIM, BYOUNG HANKR,김병한
申请号：
KR1020150191298
公开号：
KR1016427270000B1
申请日:
2015.12.31
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to an attenuated swine fever virus live marker vaccine strain and an oral administration vaccine composition using the same. More specifically, the present invention relates to an attenuated swine fever virus live marker vaccine strain (CSFV BErns attenuated C-P50) obtained by successively and continuously culturing a conventional swine fever virus vaccine strain, Flc-LOM-BErns, between cells an oral administration vaccine composition including the same and a method for serologically discerning a swine fever virus outdoor infected swine and a swine in which the attenuated swine fever virus live marker vaccine strain is inoculated. The attenuated swine fever virus live marker vaccine strain, CSFV BErns attenuated C-P50, according to the present invention has alleviated side effects of pseudo acid in a pregnant mother swine, which have been a problem of a conventional swine fever virus vaccine strain, so safety is reinforced. Moreover, the oral administration vaccine composition according to the present invention is made into bait dosage forms, so a swine can easily consumed the same. Accordingly, a problem of a conventional swine fever virus vaccine used only as an injection agent and having been difficult to be administrated in fierce bush pigs and black pigs has been solved. Furthermore, through the method according to the present invention, antigens and antibodies of a swine fever virus outdoor infected swine and a swine in which the attenuated swine fever virus live marker vaccine strain, CSFV BErns attenuated C-P50, is inoculated can be discerned, so effects of differentiating infection in vaccinated animals (DIVA) are excellent.COPYRIGHT KIPO 2016본 발명은 약독화된 돼지열병 바이러스 생마커백신주 및 이를 이용한 경구투여용 백신 조성물에 관한 것으로, 보다 구체적으로는, 기존의 돼지열병 바이러스 백신주 Flc-LOM-BErns를 세포간 교대연속배양하여 얻은 약독화된 돼지열병 바이러스 생마커백신주(CSFV BErns attenuated C-P50), 이를 포함하는 경구투여용 백신 조성물, 및 돼지열병 바이러스 야외 감염 돼지와 상기 약독화된 돼지열병 바이러스 생마커백신주 접종 돼지의 혈청학적 감별방법에 관한 것이다.본 발명에 따른 약독화된 돼지열병 바이러스 생
