PROCEDE D'IMAGERIE DE TISSU MULTIMODALE BASE SUR L'EFFET RAMAN DE RESONANCE SUR DES AGENTS DE CONTRASTE D'IRM A BASE DE METAL ET PROCEDE D'IONISATION DE PANACHES LASER PAR IONISATION CHIMIQUE A PRESSION ATMOSPHERIQUE
Disclosed herein is a method for multimodal imaging during a medicalprocedure using magnetic resonance imaging (MRI) and Raman opticalimaging which involves administering an MRI imaging contrast agent that achemical structure having charge-transfer electronic transitions. The tissueisimaged using and MRI device and the tissue is illuminated with excitationlightthat has spectral components that are approximately tuned close to one of thecharge-transfer electronic transitions thereby producing enhanced Ramanoptical signals which are analyzed to produce Raman imaging data followedby registering the MRI and Raman imaging data. The present disclosure alsoprovides a method for ionizing laser plumes through atmospheric pressurechemical ionization.
