Indiana University Research and Technology Corporation
发明人:
Mark R. Kelley,Jill Fehrenbacher
申请号：
US16850436
公开号：
US20200253904A1
申请日:
2020.04.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods of reducing neuronal sensitivity, thereby reducing inflammation and chronic pain, in subjects having diabetes are disclosed herein. Particularly disclosed are methods of administrating the apurinic/apyrimidinic endonuclease 1 redox factor 1 (APE 1/Ref-1) inhibitor, APX3330, to enhance the DNA base excision repair (BER) pathway, thereby reducing neuronal sensitivity to inflammatory mediators and alleviating inflammatory or chronic pain.
