The present invention relates to new class nuclear receptor binding agents (NRBAs).Described NRBAs is applicable to and prevents and/or treats multiple disease and illness, comprises that prevention and treatment are as the cancer of prostate cancer and breast cancer, osteoporosis, hormone relevant disease, inflammatory disease, oxidative stress related disorders, neurology illness, eye illness trouble, angiocardiopathy and obesity as Parkinsons disease and apoplexy.