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新穎之嵌段共聚物、微胞調製物及將其作為有效成分之抗癌劑
专利权人:
NIPPON KAYAKU KABUSHIKI KAISHA
发明人:
SHIMIZU, KAZUHISA,清水和久,ISHIKAWA, KEIZOU,石川惠三,NAKANISHI, TAKESHI,中西健
申请号:
TW094132581
公开号:
TWI394773B
申请日:
2005.09.21
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
A medicinal preparation is desired which has no harmful side effects such as hypersensitive reaction, heightens the water solubility of a sparingly water-soluble anticancer agent, maintains a high drug concentration in the blood, accumulates a drug in a tumor tissue at a high concentration, heightens the pharmacological effect of the sparingly water-soluble anticancer agent, and diminishes the side effects of the anticancer agent. Provided are: a novel block copolymer which can be a drug carrier having no harmful side effects such as hypersensitive reaction; a micelle preparation in which micelles are formed and which contains a sparingly water-soluble anticancer agent, especially paclitaxel, incorporated in the micelles in an amount necessary for a disease treatment without bonding it to the block copolymer and which can heighten the solubility of the drug in water; and an anticancer agent which comprises the micelle preparation as a medical ingredient, maintains a high concentration in the blood, has more potent drug activity, and is reduced in toxicity.業者期望開發一種醫藥製劑,其不具有過敏反應等有害副作用,增加水難溶性抗癌劑對水之溶解性,維持較高之藥物血中濃度,以高濃度將藥物積聚於腫瘤組織,增強該水難溶性抗癌劑之藥理效果並且減輕副作用。本發明之目的在於提供一種新穎嵌段共聚物,其可成為不表示過敏反應等有害副作用之藥物載體;微胞調製物,其可形成微胞,無需使治療疾病所需量之水難溶性抗癌劑、尤其是紫杉醇結合於該嵌段共聚物就可直接吸入微胞內,提高該藥物對水之溶解性;以及抗癌劑,其將該微胞調製物作為藥效成分,可維持較高之血中濃度,顯示更強之藥效且減輕毒性。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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