DERIVADO DE 1,3-DI-OXO-INDENO, SEU SAL FARMACEUTICAMENTE ACEITÁVEL OU ISÓMERO ÓTICO, SEU MÉTODO DE PREPARAÇÃO, E COMPOSIÇÃO FARMACÊUTICA CONTENDO O MESMO COMO INGREDIENTE ATIVO, ANTIVIRAL
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D;KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
发明人:
JOHAN NEYTS,YOUNG SIK JUNG,CHONG KGO LEE,IHL YOUNG CHOI,HAE SOO KIM,PIL HO KIM,SOO BONG HAN,HENDRIK JAN THIBAUT
申请号：
PT12799827
公开号：
PT2722322T
申请日:
2012.06.18
申请国别(地区):
PT
年份:
2019
代理人:
摘要：
The present invention relates to 1,3-dioxoindene derivatives, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient with antiviral activity. The 1,3-dioxoindene derivatives of formula (1) according to the present invention have low cyto-toxicity, and can also demonstrate utility as pharmaceutical compositions for preventing or treating viral diseases such as:； polio, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-mouth disease, blistering diseases, hepatitis A, myositis, myocarditis, pancreatitis, viral diabetes, epidemic myalgia, encephalitis, flu, herpes angina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media, and the like, since excellent antiviral activity against picornaviruses such as Coxsackie virus, enterovirus, echovirus, polio virus, rhinovirus, and the like, have been demonstrated.
