Disclosed herein is a system for decontaminating a device having a lumen. The system includes a pressure vessel defining an enclosed space having a fixed volume, and the pressure vessel has an opening. The system includes a valve positioned at the opening of the pressure vessel which is controllable between an open first position and a closed second position. The system includes a container configured to receive a device having a lumen, the container defining a wall having a section permeable to vaporized decontaminating substance. The enclosed space of the pressure vessel is configured to be in fluid communication with the lumen of the device and the valve configured to control a flow between the lumen and the enclosed space.
