Xiao-Yan ZHAO,Andreas WILMEN,Christoph FREIBERG,Lars LINDEN,Ji-Yun KIM,Subramanian YEGNESWARAN,Karin REGNSTROM,Ursula EGNER,Xinquan WANG
申请号：
US15775056
公开号：
US20180326053A1
申请日:
2016.11.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided are optimized humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. In particular, the antibodies bind to particular epitopes outside the catalytic triad of the active site of human activated protein C. Methods of treatment employing these antibodies are described herein.
