PROBLEM TO BE SOLVED: To provide a vaccine pharmaceutical composition for transdermal administration which is safety, is useful as the preventive or therapeutic agent of cancer or infection, and can induce a systemic immune response safely and effectively.SOLUTION: The invention provides a vaccine pharmaceutical composition for transdermal administration which is administered to the skin of a human or an animal comprising, as an immunostimulant, at least one specific lipopolysaccharide derived from Gram negative bacterium or a salt thereof, and at least one antigen, wherein the mass ratio of the above immunostimulant and the antigen (the total mass of the immunostimulant/the total mass of the antigen) is 0.002-500.SELECTED DRAWING: None【課題】安全で、癌又は感染症の予防又は治療剤として有用で、安全かつ効果的に全身性免疫応答を誘導させることのできる経皮投与用ワクチン医薬組成物を提供する。【解決手段】ヒト又は動物の皮膚に投与される経皮投与用ワクチン医薬組成物であって、免疫賦活化剤として、少なくとも１種の特定のグラム陰性細菌由来のリポポリサッカライド又はその塩と、少なくとも一種類の抗原とを含み、上記免疫賦活化剤と前記抗原との質量比（免疫賦活化剤の総質量／抗原の総質量）が、０．００２～５００である経皮投与用ワクチン医薬組成物。【選択図】なし
