NIETO CALLEJO, MARIA LUISA,MARTIN MONTANA, RUBEN,CARVALHO TAVARES, JULIANA,RUIZ GUTIERREZ, VALENTINA
申请号：
EP09724203
公开号：
EP2260851A4
申请日:
2009.02.12
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The invention relates to the use of pentacyclic triterpene for the preparation of a pharmaceutical compound intended for the treatment of multiple sclerosis. Oleanolic acid (3ss-hydroxyolean-12-en-28-oic acid) is a pentacyclic triterpene acid present in a large number of medicinal plants. The invention relates to the pharmacological use of oleanolic acid either alone or combined with other substances in the therapy or prophylaxis of neurodegenerative diseases, such as multiple sclerosis. The applicants have found that the daily intraperitoneal administration of oleanolic acid significantly reduces the neurological and immunoinflammatory symptoms associated with experimental autoimmune encephalomyelitis, an experimental model of multiple sclerosis, delaying the onset and reducing the progression of the disease
