ВИРЗ Джеффри (US),ХУАНГ Дэниэл (US),МИЛЛЕР Дэнфорт (US),РАО Нагараджа (US),ТАРАРА Томас Э. (US)
申请号：
RU2013140706/15
公开号：
RU2013140706A
申请日:
2012.02.03
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A dry powder composition for inhalation containing spray dried particles that contain a core of the first active ingredient in a substantially crystalline form, which is coated with a layer of the second active ingredient in a substantially amorphous form, which is dispersed in a pharmaceutically acceptable hydrophobic excipient. The composition according to claim 1, wherein the active ingredients are selected from bronchodilating, anti-inflammatory, antihistamines, decongestants, and antitussive drugs. The composition of claim 2, wherein the first active ingredient is a β2 agonist and the second active ingredient is a steroid. The composition of claim 2, wherein the first active ingredient is a β2 agonist and the second active ingredient is an anti-muscarinic antagonist. The composition of claim 2, wherein the first active ingredient is a β2 agonist, the second active ingredient is an anti-muscarinic antagonist, and the composition also contains a third active ingredient, which is a steroid. The composition according to claim 1, which further comprises a third active ingredient, which is essentially amorphous and dispersed in a hydrophobic excipient. The composition of claim 6, wherein the active ingredients are indacaterol or a salt thereof, mometasone furoate and glycopyrrolate. The composition of claim 1, wherein the hydrophobic excipient is a phospholipid. The composition according to claim 1 in powder form, in which the particles of an inhaled drug contain from 0.1% to 30% weight / weight of the first active ingredient�1. Сухая порошковая композиция для ингаляции, содержащая высушенные распылением частицы, которые содержат ядро из первого активного ингредиента в по существу кристаллической форме, которое покрыто слоем второго активного ингредиента в по существу аморфной форме, который диспергирован в фармацевтически приемлемом гидрофобном эксципиенте.2. Композиция по п.1, в которой активные ингредиенты выбирают из бронхорасширяющих, противовоспалительных, а
