There is disclosed a guidewire, comprising: an elongate body dimensioned for insertion into a lumen within a body； and a sensing tip electrically and mechanically coupled to the elongate body, the sensing tip being configured to interface with the wall of the lumen and to convey one or more electrophysiological signals associated with an electrophysiological activity in the vicinity of an anatomical site of interest within the vicinity of the lumen； wherein the sensing tip comprises a plurality of electrodes disposed on a flexible substrate, the flexible substrate being rolled to form the sensing tip.
