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Compounds and Pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis
专利权人:
LES LABORATOIRES SERVIER;GALAPAGOS NV
发明人:
申请号:
ARP150104189
公开号:
AR103170A1
申请日:
2015.12.18
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
Claim 1: a compound according to formula (1), where: r u00b9 is c u2081 u208b u2084: H, alkyl,Optionally substituted with one or more of the groups r u2074 independently selected; c u2083 u208b u2087 monocyclic cycloalkyl optionally replaced with groups r u2074,Independently Selected heterocicloalquilo monocyclic; 4 - 7 members, comprising 1 to 2 heteroatoms selected, regardless of N, o, and SOptionally substituted with one or more c u2081 u208b u2084 alkyl, - C (= o) c u2081 u208b u2084, or alkyl, - C (= o) oc u2081 u208b u2084 alkyl, phenyl, Selected independently;Optionally substituted with one or More groups r u2075 independently selected FUSED to heterocicloalquilo monocyclic; phenyl 5 - 6 members, comprising 1Two or three heteroatoms selected regardless of N, o, and S, which heterocicloalquilo is optionally substituted with one or more monocyclic heteroaryl = 5 or 6 members.Comprising 1 to 2 heteroatoms selected, regardless of N, o, and SOptionally substituted with one or More groups r u2075 independently selected; R u00b2 is independently selected from: H, Oh, c u2081 u208b u2084 alkoxy,And c u2081 u208b u2084 alkyl, optionally substituted with one of: Oh, CN, c u2081 u208b u2084 alkoxy optionally substituted with phenylMonocyclic heteroaryl or 5 - 6 members comprising 1 or 2 heteroatoms selected regardless of N, o, and SOptionally substituted with one or more alkyl c u2081 u208b u2084 independently selected; each r u00b3 u1d43, and r u00b3 u1d47 is independently selected from h,:And c u2081 u208b u2084 alkyl or aryl: CY is a monocyclic or bicyclic FUSED 6 to 10 members,Optionally substituted with one or More groups r u2076 independently selected; a monocyclic or bicyclic heteroaryl FUSED 5 - 10 members, including 1Two or three heteroatoms selected regardless of N, o and S, optionally substituted with one or More groups r u2076, regardless is replaced; r u2074 Halo, Oh, - CN, c u2081 u208b u2084 alkylC u2081 u208b u2084 alkoxy optionally substituted with alko
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