The quality of a parametric map is improved based upon information contained in optoacoustic images. Frames are acquired by a multi-wavelength optoacoustic imaging system. A first sub-set including uncorrelated frames from a first wavelength is generated. A first interframe artifact estimate is generated. The first artifact estimate is applied to a frame from a first wavelength to mitigate the interframe persistent artifact in the frame, creating a first processed frame. A second sub-set including uncorrelated frames from a second wavelength is generated. A second interframe artifact estimate is generated. The second artifact estimate is applied to a frame from the second wavelength to mitigate the artifact in the frame from the second wavelength, creating a second processed frame. A parametric map is generated from information in the first processed frame and information in the second processed frame.
