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체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료 시에 NHE-매개된 역수송을 억제하는 화합물 및 방법
专利权人:
알데릭스, 인코포레이티드
发明人:
차모트, 도미니크,제이콥스, 제프리, 더블유.,레드베터, 마이클, 로버트,네브레, 마크,카레라스, 크리스,벨, 노아
申请号:
KR1020177021507
公开号:
KR1020170091783A
申请日:
2009.12.30
申请国别(地区):
KR
年份:
2017
代理人:
摘要:
The invention heart failure (particularly, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome growth factor-activated receptor (PPAR) gamma agonists - fluid retention, or salts, such as the induced fluid retention It relates to compounds and methods for treating disorders associated with the overload. The invention also relates to compounds and methods for the treatment of high blood pressure. The invention also relates to containing the treatment or reduction of pain associated with gastrointestinal dysfunction, compounds and methods for the treatment of gastrointestinal disorders. The method, in general, necessary to mammalian gastrointestinal (GI) of the tube that sodium ions and hydrogen ions in the in the NHE- that are designed to be substantially active in inhibiting mediated yeoksusong compound or pharmaceutical composition comprising such a compound of it comprise administering a pharmaceutically effective amount. More particularly, the method comprising inhibiting a mammal in need of a sodium ion and NHE-3, -2 and / or -8-mediated yeoksusong of hydrogen ions in the GI tract, and the epithelial cell layer, and more particularly the epithelial layer of the GI tract in a substantially light comprises administering a pharmaceutically effective amount of a pharmaceutical composition comprising a compound or compounds of these designs such that the transmissivity. To the compound is substantially impermeable result, this is not absorbed, and thus other internal organs essentially a non-systemic exposure that is limited (e. G., Liver, heart, brain, etc.) thereof-is bioavailability. How to provide the capability to act as by administration with the water absorbent polymer discussed the combination described above, and further isolate the fluid and / or salt present in the GI tract - the present invention also provides such a compound to a mammal fluid It relates.본 발명은 심부전 (특히, 울혈성 심부전), 만성 신장질환, 말기 신장 질환, 간 질환,
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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