Pyridopyrimidine or pyrimidopyrimidine compound, preparation method, pharmaceutical composition and use thereof

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专利权人:

Fudan University;Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Chinese Academy of Sciences;Shanghai Institute of Materia Medica

发明人:

Shen, Jingkang,Yu, Ke,Meng, Tao,Ma, Lanping,Zask, Arie,Meng, Lanfang,Wang, Xin,Chen, Yiyi

申请号：

AU2014225155

公开号：

AU2014225155A1

申请日:

2014.02.28

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

The present invention relates to the field of pharmaceutical chemistry. In particular, the present invention relates to a pyridopyrimidine or pyrimidopyrimidine compound as represented by general formula (I), or an isomer thereof or a pharmaceutically acceptable salt, ester, prodrug or solvate thereof, a preparation method, a pharmaceutical composition and uses thereof in preparing an mTOR inhibitor. As the mTOR inhibitor, the compound or the pharmaceutical composition thereof can be used for treating the diseases or symptoms due to PI3K-AKT-mTOR signal path malfunction.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/