Cosmetic or pharmaceutical composition (A) comprises as soothing active ingredient, a peptide hydrolyzate enriched in bioactive peptide capable of enhancing the barrier function of the epidermis, where the bioactive peptide contains 3-5 amino acids with at least one glycine residue and a lysine residue, in a medium. ACTIVITY : Dermatological; Antiinflammatory; Antipruritic; Antiallergic; Endocrine-Gen. MECHANISM OF ACTION : 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activator; Interleukin-1 alpha production inhibitor.