ALK Pharmaceutical composition for inducing the degradation of ALK protein and pharmaceutical composition for use in preventing or treating cancer containing the same as an active ingredient
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;한국화학연구원
发明人:
HWANG, JONG YEON,황종연,HA, JAE DU,하재두,KIM, HYOUNG RAE,김형래,CHO, SUNG YUN,조성윤,JUNG, HEE JUNG,정희정,KIM, PIL HO,김필호,YUN, CHANG SOO,윤창수,LEE, CHONG OCK,이정옥,PARK, CHI HOON,박지훈,HWANG, JONG YEONKR,HA, JAE DUKR,KIM, HYOUNG RAEKR,CHO, SUNG YUNKR,JUNG, HEE JUNGKR,KIM, PIL HOKR,YUN, CHANG SOOKR,LEE, CHONG OCKKR,PARK, CHI HOONKR
申请号：
KR1020160063391
公开号：
KR1020170132934A
申请日:
2016.05.24
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a method for producing a medicine inducing the degradation of ALK protein and a pharmaceutical composition for preventing or treating cancer containing the medicine as an active ingredient. A compound represented by chemical formula 1 according to the present invention can inhibit or degrade anaplastic lymphoma kinase (ALK), and thus has a useful effect for the prevention and treatment of diseases associated with anaplastic lymphoma kinase (ALK), for example, cancer.ALK 단백질의 분해를 유도하는 약물의 제조 방법 및 이를 유효성분으로 합유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 화학식 1로 표시되는 화합물은 역형성 림프종 키나제(ALK)를 억제하거나 분해시킬 수 있어, 역형성 림프종 키나제(ALK) 관련 질환, 예를 들어 암의 예방 및 치료에 유용한 효과가 있다.
