The present invention is generallydirected to compositions and methods for the treatmentof an infectious disease of the foot of an animal.One aspect of the invention is directed to amethod for preventing and/or treating one or moreinfectious diseases of the hoof in animals, comprising:preparing a copper-free and zinc-free compositioncomprising at least one cross- linking agent,wherein the cross-linking agent is not formaldehyde；and administering the composition to a lowerleg and hoof area of said animal to prevent and/ortreat said one or more infectious diseases. Anotheraspect of the invention is directed to a copper-freeand zinc-free composition for the treatment and/orprevention of one or more infectious diseases of thehoof in animals, comprising at least one cross-linkingagent, wherein said cross-linking agent is notformaldehyde. The present invention is also directedto a method for treating and / or preventing papillomatousdigital dermatitis in an ungulate, comprising:preparing a copper-free and zinc- free compositioncomprising at least one cross-linking agentand at least one quaternary ammonium compound；and spraying or applying in a foam a therapeuticallyeffective amount of said composition to a lowerleg and hoof area of said ungulate in order to treatand/or prevent said papillomatous digital dermatitis.
