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IDENTIFICATION, OPTIMISATION ET UTILISATION D'ÉPITOPES HLA-B7 CRYPTIQUES POUR UNE IMMUNOTHÉRAPIE
专利权人:
VAXON BIOTECH
发明人:
申请号:
EP07825358.0
公开号:
EP2041160B1
申请日:
2007.07.12
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The invention provides methods for identifying a HLA-B*0702-restricted cryptic epitope in an antigen, as well as methods for increasing the immunogenicity of HLA-B*0702-restricted cryptic epitopes. The HLA-B*0702-restricted cryptic epitopes and their cognate immunogenic epitopes are useful for stimulating an immune reaction against the cryptic epitopes in a subject. Accordingly, the invention further provides pharmaceutical compositions comprising a HLA-B*0702-restricted cryptic epitope or a cognate immunogenic epitope thereof, and vaccination kits comprising such epitopes. The novel materials of the invention are particularly useful for efficiently treating patients having an HLA-B*0702 phenotype.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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