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NERVE GROWTH FACTOR COMPOSITION AND POWDER INJECTION
专利权人:
STAIDSON (BEIJING) BIOPHARMACEUTICALS CO., LTD.;BEIJING STAIDSON MEDICAL TECHNOLOGY CO., LTD.
发明人:
Jianping TAN,Bingzhang WANG
申请号:
US15568453
公开号:
US20180104310A1
申请日:
2016.04.18
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention discloses a nerve growth factor composition and an injection powder comprising a nerve growth factor, a stabilizer, a pH buffer, and water, wherein the stabilizer is at least one of sorbitol, dextran, trehalose, raffinose and mannitol. By using a carbohydrate or sugar alcohol as a stabilizer, the present invention can avoid the potential risk resulting from the presence of viruses or other unknown components in albumin. In addition to the nerve growth factor, only the stabilizer and the pH buffer are contained, without conventional surfactant and supporting agent, increasing safety and significantly reducing incidence of the adverse reactions. The present invention not only provides a protective effect on mNGF, but also can ensure good stability of hNGF and rhNGF in the preparation, transportation and storage processes, and has better medication safety and quality control.
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