Boopathy RAMAKRISHNAN,Brian BOOTH,Karthik VISWANATHAN,Kristin NARAYAN,Andrew M. WOLLACOTT
申请号：
MX2019001458
公开号：
MX2019001458A
申请日:
2017.08.02
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
Polypeptides, such as antibody molecules and fusion proteins, comprising an Fc region, are disclosed. The polypeptides can be used to treat, prevent, and/or diagnose disorders. In particular, Fc regions comprising either one or multiple mutations selected from the partcicular mutations disclosed in Table 1 are disclosed. Certain of said mutations result in increased affinity for the neonatal Fc receptor (FcRn), and certain of said mutations result in ehnaced half-life of engineered antibodies and also have an impact on effector functions. Particular disclosed mutations are M252Y, S254T, T256E, L309N, T250Q, M428L, N434S, N434A, T307A, E380A, N434A, M252Y, S254T, T256E, or a combination thereof as e.g. T256D/Q311V/A378V, H285N/ T307Q/N315D, H285D/T307Q/A378V, T307Q/Q311V/A378V, T256D/ N286D/T307R/Q311V/A378V, or T256D/T307R/Q311.Se describen polipéptidos, tales como moléculas de anticuerpo y proteínas de fusión, que comprenden una región Fc. Los polipéptidos pueden utilizarse para tratar, prevenir, y/o diagnosticar enfermedades.
