PURPOSE: An external use skin composition containing Bombyx mori L. feces extract with anti-inflammation effect is provided to enhance expression of heme oxygenase-1 and sirtuin. CONSTITUTION: A Bombyx mori L. feces extract with anti-inflammation effect contains bis-norsesquiterpene compounds, flavene compounds, or lignin compounds. The bis- norsesquiterpene compound contains a compound selected from compound 1-5. An external use skin composition for anti-inflammation contains the Bombyx mori L. feces extract as an active ingredient. The composition is a cosmetic composition or medicinal composition.본 발명은 항염증 효과를 갖는 잠분 추출물 및 이를 포함하는 피부 외용제 조성물에 관한 것이다. 보다 상세하게 상기 잠분 추출물은 헴 옥시게나제- 1과 시르투인1의 발현을 증대시켜 항염증 효과를 갖는다.
