Bonnie L. Bassler,Lee R. Swem,Scott M. Ulrich,Colleen T. OLoughlin
申请号：
US12643574
公开号：
US08247443B2
申请日:
2009.12.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote Caenorhabditis elegans from quorum-sensing-mediated killing by the bacterial pathogen Chromobacterium violaceum. The saving of C. elegans demonstrates the use of these molecules as small molecule antimicrobials.
