Antimicrobial composition contains bacterio¬phage strains sensitive to Staphylococcus aureus: DSM 32631, DSM 32629, DSM 32630, bacterio¬pha¬ge strains sensitive to Streptococcus pyogenes: DSM 32634, DSM 32635, bacteriophage strains sensitive to Escherichia coli: DSM 32612, DSM 32611, DSM 32610, bacteriophage strains sensitive to Proteus vulgaris: DSM 32613, DSM 32614, DSM 32615, bacteriophage strains sensitive to Pseudomonas aeruginosa: DSM 32616, DSM 32618, DSM 32617 and optionally pharmaceuti¬cally acceptable excipient. At that, all said bacteriophages are deposited in the German Collection of Microorganisms and Cell Cultures (DSMZ). The composition is used at the treatment and/or as prevention of purulent-inflammatory in people, animals and birds, as well.