HARRISON TIMOTHY,O&rsquoDOWD COLIN,SHEPHERD STEVEN,TREVITT GRAHAM,ZHANG LIXIN,BURKAMP FRANK
申请号：
NZ63058013
公开号：
NZ630580A
申请日:
2013.03.25
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed are compounds of Formula (I) that are useful as inhibitors of the activity of one or more isoforms of the serine / threonine kinase AKT. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer. Examples of a compound of formula (I) are: 6-(4-((1s,3s)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenyl-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one 6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-7-methyl-5-phenyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
