Devices and methods for sealing and cutting tissue are provided in one exemplary embodiment, the device includes a proximal handle portion, an elongate shaft, and a jaw assembly having first and second jaws. At least one of the jaws includes an electrode that is segmented into a plurality of zones. Each zone includes a parameter monitor, and the parameter monitors provide information about the tissue that is then mapped to define one or more characteristics of the tissue. A controller can then be operated to adjust functionality of the device within each zone based on the mapped parameters/characteristics. Other devices and methods for sealing and cutting tissue are also provided.