The present invention relates to a device for detoxification of one of plasma and plasma water. The device includes at least one separator (421) for separating at least one of blood cells and molecules of high and medium molecular weight from blood andat least one clearance or removal compartment (465) that comprises one or more aptamers to remove at least one of uremic toxins, groups of uremic toxins and precursor molecules of uremic toxins from the passing fluid of plasma or plasma water, such that the fluid of plasma or plasma water treated by the at least one clearance or removal compartment (465) can be returned directly to the blood.
