TFPI INHIBITORS AND METHODS OF USE农业专利-农业专业知识服务系统

发明人:: DOCKAL, MICHAEL,多卡尔麦克,多卡爾麥克,HARTMANN, RUDOLF,哈特曼鲁道夫,哈特曼魯道夫,FRIES, MARKUS,福理斯马克思,福理斯馬克思,SCHEIFLINGER, FRIEDRICH,雪佛玲格费德瑞奇,雪佛玲格費德瑞奇,EHRLICH, HARTMUT,赫里基哈穆,赫里基哈穆,REINEKE, ULRICH,兰内克乌莉希,蘭內克烏莉希

摘要：: The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.本發明提供結合組織因子路徑抑制劑(TFPI)之肽,包括TFPI抑制肽;及其組成物。該等肽可用於抑制TFPI、增強凝血因子不足之個體中之凝血酶形成、增加個體中之血凝塊形成、治療個體之凝血病症、純化TFPI及鑑別TFPI結合化合物。