Disclosed herein are methods for treating or preventing a hypoperfusion related disease in a subject in need thereof, comprising identifying a subject with cerebral hypoperfusion and administering an effective amount of an α5β1 integrin inhibitor to the subject. Methods for decreasing α5β1 expression in the cerebrovasculature, comprising: administering an effective amount of an α5β1 integrin inhibitor to a subject in need thereof are also disclosed. A method for preventing or decreasing the risk of developing diabetes related dementia, comprising: identifying a subject with diabetes and administering an effective amount of an α5β1 integrin inhibitor to the subject is further disclosed.
