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Pharmaceutical formulation of racecadotril
专利权人:
Rivopharm SA
发明人:
Poli, Piero,Fiorino, Alessandro,Piazzolla, Tommaso Roberto
申请号:
AU2015382526
公开号:
AU2015382526A1
申请日:
2015.12.23
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
The object of the present invention is a pharmaceutical formulation of racecadotril characterized by high bioavailability. In particular, the present invention relates to a method of dry granulating racecadotril in the presence of a hydrophilic excipient and a disintegrant, preferably with a low moisture content; said method being carried out by means of a tablet machine or alternately a roller compacting machine, carrying out the compaction step with a compaction strength of less than 30 kN and equal to or greater than 4 kN, and the step of grinding the slugs and screening so as to obtain a granulate in which not more than 50% by weight of the product has a particle size of less than 90 micron.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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