A compound as an isocitrate dehydrogenase inhibitor, and an application thereof, which belongs to the pharmaceutical / chemical field, specifically, a compound represented by the formula I or an isomer thereof, a pharmaceutically acceptable salt, a crystal, Solvates or prodrugs, methods for their preparation, and pharmaceutical compositions containing these compounds, as well as applications of those compounds or compositions. Such compounds have very good mutant IDH2 enzyme activity and ability to inhibit mutant IDH2 tumor cells and can be applied to the prevention and / or treatment of tumors characterized by the presence of mutant IDH2.イソクエン酸デヒドロゲナーゼ阻害剤としての化合物、及びその応用であって、医薬・化学分野に属し、具体的には、式Ｉで表される化合物又はその異性体、薬学的に許容される塩、結晶、溶媒和物、又はプロドラッグ、それらの製造方法、及びそれらの化合物を含む医薬組成物、並びにそれらの化合物又は組成物の応用である。かかる化合物は、非常に良好な、変異型ＩＤＨ２酵素活性及び変異型ＩＤＨ２腫瘍細胞の阻害功能があり、変異型ＩＤＨ２の存在を特徴とする腫瘍の予防及び/又は治療に適用できる。
